Relationship between smooth er and drug tolerance

Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes.

Slide List. Proliferation of Smooth ER As the cell becomes better equipped to modify the drugs, this proliferation leads to drug tolerance. Hide Labels. smooth endoplasmic reticulum induction of barbiturates leads to a state of tolerance, with a decrease in the effects of the drug and the need. ENDOPLASMIC RETICULUM AND DRUG-METABOLIZING ENZYMES .. The parallelism suggests a close relationship between this microsomal cytochrome Such an adaptive enzyme induction explains the tolerance developed with re-.

BiologyWise Staff Last Updated: Ribosomes are concerned with protein synthesis. RER is more prominent in liver cells, as they are concerned with the production of proteins. So, cells specializing in protein synthesis have more prominent RER, while SER is prominent in those cells, which are concerned with the production of lipids.

All these structures tubules and sacs are held in their place by the cytoskeleton. The ER remains bound by a phospholipid membrane. Inside the membrane, a fluid-filled space exists, which is known as cisternal space or lumen. The lumen or cisternal space is continuous with the perinuclear space. A part of ER is also continuous with the nuclear envelope.

SER does not contain this cell organelle, and hence the name smooth endoplasmic reticulum. Another type of endoplasmic reticulum is Sarcoplasmic Reticulum, which is a type of specialized SER that can be found in smooth, as well as striated muscles. The functions of SER can vary to an extent depending on the type of cell. More commonly, it is concerned with carrying out certain metabolic processes. Carbohydrate and Lipid Synthesis Smooth Endoplasmic Reticulum SER is mainly concerned with the synthesis of carbohydrate and lipids, and sometimes, with their metabolism.

Steroid hormones are produced in SER present in the adrenal and endocrine glands. At the center of it all is the nucleus, which contains DNA, the genetic material we learned about in our last Instruction.

How do drug users gain tolerance for a drug? | Physics Forums

Ribosomes These are relatively tiny organelles. There are two different kinds of ribosomes: If a protein is going to be used inside the cytoplasm of a cell, it is generally built by free ribosomes and not by ones bound to the endoplasmic reticulum. There are two different kinds of ER: It is the site of the synthesis of fatty acids and phospholipids. It is shaped like little tubes, as you can see in this illustration: Smooth ER creates steroids and stores ions so that the cell can have them when it needs them.

How do drug users gain tolerance for a drug?

The word ion just means that a molecule has a charge. The storage of steroids and ions is kind of like keeping extra money in a savings account for when you need it later. It detoxifies poisonous substances in the liver, for example. Smooth ER actually has an association with drug tolerance. As people consume more alcohol, they realize that they have to continue to drink more to get the same effect. This happens because more inactivating enzymes are being produced. These inactivating enzymes are responsible for helping to detoxify the liver.

The largest number of bound ribosomes is found in cells that produce secretory products. These secretory proteins enzymes are manufactured here. The term secretory just means that these proteins are made for secretion, or delivery outside the cell, into the body. Once a protein has been synthesized madeRough ER creates a bubble around it by pinching off a portion of its own membrane.